Stem cells may be able to repair broken hearts, a small new study in monkeys finds.
In the study, the researchers transplanted heart muscle cellsthat were made from the stem cells of a macaque into the damaged hearts of five other macaques.
The transplanted cells integrated with the monkeys’ own heart muscle cells and allowed their damaged hearts to function better, according to the study, published today (Oct. 10) in the journal Nature.
However, because the study was conducted in a small group of young macaques, more research is needed to see if this procedure would work in humans. [10 Amazing Facts About Your Heart]
Previous studies have suggested that heart muscle cells derived from stem cells may hold promise for repairing damaged hearts, the researchers wrote in the study, published today (Oct.10) in the journal Nature.
Ideally, these heart muscle cells would be created using a patient’s own stem cells, as research has shown that such cells are less likely to be rejected by the patient’s immune system, according to the study.
But because the researchers wanted to transplant cells into the hearts of several monkeys as opposed to just one monkey, it would have been expensive and difficult to manufacture personal cells from each individual monkey. A cheaper and easier alternative involves using cells that come from one donor for several recipients — though there is a higher risk of rejecting such cells by the recipient’s immune system that may recognize them as foreign, the researchers said.
To prevent transplant rejection, the researchers made sure that a specific protein found in the donor was as similar as much as possible to the same protein found in the recipient cells. Doing so was an effort to “trick” the immune system into recognizing the foreign cells as the recipient’s own cells and not reject them, the researchers said.
After the transplants, the researchers studied the macaques for three months. They found that the newly transplanted cells integrated with the macaques’ own heart cells; in other words, the macaques’ immune systems did not reject the new cells. In addition, their hearts’ ability to contract improved after the muscle cells were transplanted, the researchers wrote. [Top 3 Techniques for Creating Organs in the Lab]
The researchers noted that the macaques became more prone to experiencing irregular heartbeats after receiving the transplanted cells.
These irregular heartbeats lasted up to four weeks after the transplants, said study co-author Dr. Yuji Shiba, an associate professor of cardiovascular medicine at Shinshu University.
The side effect was not deadly, however, and all of the macaques lived for the entire three-month study period, Shiba told Live Science.
The animals were euthanized at the end of the study period, and therefore it is not clear whether the immune system would not still reject the transplanted cells after a period that’s longer than the three-month review, according to the study.
Abstract Background Cell-to-cell heterogeneity is a major driver of cancer evolution, progression, and emergence of drug resistance. Epigenomic variation at the single-cell level can rapidly... Read more →