Patch delivers drug, gene, and light-based therapy to tumor sites
The researchers have developed a triple-therapy hydrogel patch, which can be used to treat tumors locally. This is particularly effective as it can treat not only the tumor itself but any cells left at the site after surgery, preventing the cancer from recurring or metastasizing in the future.</p> <p>Firstly, the patch contains gold nanorods, which heat up when near-infrared radiation is applied to the local area. This is used to thermally ablate, or destroy, the tumor.
These nanorods are also equipped with a chemotherapy drug, which is released when they are heated, to target the tumor and its surrounding cells.Finally, gold nanospheres that do not heat up in response to the near-infrared radiation are used to deliver RNA, or gene therapy to the site, in order to silence an important oncogene in colorectal cancer</a>. Oncogenes are genes that can cause healthy cells to transform into at no cells that are likely to cause cancer recurrence remain at the site. As the patch degrades, it will gradually release the various therapies.</p>
The patch can also serve as a neoadjuvant, a therapy designed to shrink tumors prior to their resection, Artzi says.
When the researchers tested the treatment in mice, they found that in 40 percent of cases where the patch was not applied after >tumor removal, the cancer returned.
But when the patch was applied after surgery, the treatment resulted in complete remission.Indeed, even when the tumor was not removed, the triple-combination therapy alone was enough to destroy it.
Unlike existing colorectal cancer surgery, this treatment can also be applied in a minimally invasive manner. In the next phase of their work, the researchers hope to move to experiments in larger models, in order to use colonoscopy equipment not only for cancer diagnosis but also to inject the patch to the site of a tumor, when detected.”This administration modality would enable, at least in early-stage cancer patients, the avoidance of open field surgery and colon resection,” Artzi says. “Local application of the triple therapy could thus improve patients’ quality of life and therapeutic outcome.”