• 63

    SOURCE

    July 2016

    (Nanowerk News) Research completed through a collaboration with University of Missouri engineers, biologists, and chemists could transform how scientists study molecules and cells at sub-microscopic (nanoscale) levels. Shubra Gangopadhyay, an electrical and computer engineer and her team at MU recently published studies outlining a new, relatively inexpensive imaging platform that enables single molecule imaging. This patented method highlights Gangopadhyay’s more than 30 years of nanoscale research that has proven invaluable in biological research and battling diseases.

    This diagram shows the difference between regular and plasmonic gratings in terms of fluorescent intensity. (Image: Shubhra Gangopadhyay/Nanoscale)”Usually, scientists have to use very expensive microscopes to image at the sub-microscopic level,” said Gangopadhyay, the C.W. LaPierre Endowed Chair of electrical and computer engineering in the MU College of Engineering. “The techniques we’ve established help to produce enhanced imaging results with ordinary microscopes.

    The relatively low production cost for the platform also means it could be used to detect a wide variety of diseases, particularly in developing countries.”The team’s custom platform uses an interaction between light and the surface of the metal grating to generate surface plasmon resonance (SPR), a rapidly developing imaging technique that enables super-resolution imaging down to 65 nanometers–a resolution normally reserved for electron microscopes.

    Using HD-DVD and Blu-Ray discs as starting templates, a repeating grating pattern is transferred onto the microscope slides where the specimen will be placed. Since the patterns originate a widely used technology, the manufacturing process remains relatively inexpensive.”In previous studies, we’ve used plasmonic gratings to detect cortisol and even tuberculosis,” Gangopadhyay said. “Additionally, the relatively low production cost for the platform also means it could be used to further detect a wide variety of diseases, particularly in developing countries.

    Eventually, we might even be able to use smartphones to detect disease in the field.”Gangopadhyay’s work also highlights the collaborations that are possible at the Mizzou. Working with the MU Departments of Bioengineering and Biochemistry, the team is helping to develop the next generation of undergraduate and graduate students. Patents and licenses developed by MU technologies help create and enhance relationships with industry, stimulate economic development, and impact the lives of state, national and international citizens.

    “Plasmonic gratings with nano-protrusions made by glancing angle deposition (GLAD) for single-molecule super-resolution imaging” recently was published in Nanoscale, a journal of the Royal Society of Chemistry. The National Science Foundation provided partial funding for the studies. The content is solely the responsibility of the authors and does not necessarily represent the official views of the funding agency.

    Source: University of Missouri-Columbia

    Read more: New nanoscale technologies could revolutionize microscopes, study of disease

     
     

    No comments

    Be the first one to leave a comment.

    Post a Comment


     

     

    Latest Posts

    2017 Update on obstetrics

    These experts discuss the practical clinical implications of new society recommendations for antenatal steroid administration, low-dose aspirin for preeclampsia prevention,... Read more →

    Latest Video

     
     

    LATEST POSTS

    Glaucoma gene therapy on positive trajectory using CRISPR-Cas9

    SOURCE May 02, 2016 Seattle—Results from a series of preclinical studies are providing proof of principle that gene targeting using…

    Mark Bertolini: The new definition of Quality in Healthcare is Convenience

      “… in studying the healthcare system we know one thing: the cheapest place to provide care is in the…

    Gentle Bot: 3D printing a robot with feelings

      3D printing is enabling strong advances in the field of soft robotics. New research from Cornell University has created robotic hands…

    Multiregional brain on a chip

     SOURCE (Nanowerk News) Harvard University researchers have developed a multiregional brain-on-a-chip that models the connectivity between three distinct regions of…

    2017 Update on obstetrics

    These experts discuss the practical clinical implications of new society recommendations for antenatal steroid administration, low-dose aspirin for preeclampsia prevention,…

    Stem cells grow cartilage to fix hips

    A 3D scaffold has been molded into the precise shape of a hip joint. The scaffold is covered with cartilage…

    Tool predicts if prostate cancer will return after surgery

    SOURCE A tool that analyzes the expression patterns of four genes might help doctors predict if prostate cancer will reoccur…

    New way of imaging eyes could spot glaucoma sooner

    SOURCE A new imaging technique has given researchers the first look at individual cells at the back of the eye…